After receiving his doctorate from the Technical University of Berlin in 1983, Lindau was a postdoctoral associate at the Max-Planck-Institute for Biophysical Chemistry in Göttingen and at the Free University of Berlin, where he became an assistant professor in 1988. From 1992 through 1997 he was an associate member of the Max-Planck-Institute for Medical Research and taught biophysics at the University of Heidelberg. He joined the faculty at Cornell in 1997. He is active as a consultant in the areas of biophysics, physiology, and cell biology, and is a member of the Biophysical Society and the Society for Neuroscience.
The aim of our research is to achieve a mechanistic understanding of the molecular nanomachine that releases neurotransmitters, hormones and other compounds from secretory cells in the body. Several molecular components of this nanomachine have been identified as recognized in the 2013 Nobel Prize in Physiology or Medicine. However, we still don't understand how the machine works. We use biophysical, computational and molecular techniques to understand the molecular motions that open the gate, which releases the transmitter molecules stored in secretory vesicle inside the cell to the outside of the cell.
- Zhao, Y., Q. Fang, A. D. Herbst, K. N. Berberian, W. Almers, Manfred Lindau. 2013. "Rapid structural change in synaptosomal-associated protein 25 (SNAP25) precedes the fusion of single vesicles with the plasma membrane in live chromaffin cells." Proc. Natl. Acad. Sci. U S A (110): 14249-54.
- Kim, Brian, Adam D. Herbst, Sung J. Kim, Bradey A. Minch, Manfred Lindau. 2013. "Parallel recording of neurotransmitters release from chromaffin cells using a 10x10 CMOS IC potentiostat array with on-chip working electrodes." Biosens Bioelectron (41): 736-44.
- Fang, Q., Y. Zhao, Manfred Lindau. 2013. "Juxtamembrane tryptophans of synaptobrevin 2 control the process of membrane fusion."FEBS letters 587 (1): 67-72.
- Lindau, Manfred, B. A. Hall, A. Chetwynd, O. Beckstein, M. S.P. Sansom. 2012. "Coarse-Grain Simulations Reveal Movement of the Synaptobrevin C-Terminus in Response to Piconewton Forces." Biophysical Journal 103 (5): 959-969.
- Ngatchou, A. N., K. Kisler, Q. Fang, A. M. Walter, Y. Zhao, D. Bruns, J. B. Sorensen, Manfred Lindau. 2010. "Role of the synaptobrevin C terminus in fusion pore formation." PNAS 107 (43): 18463-18468.
Selected Awards and Honors
- 2018 Sir Bernard Katz Award (the Biophysical Society Exocytosis and Endocytosis Subgroup) 2018
- Tau Beta Pi Engineering Honors Society Teaching Award (Tau Beta Pi) 2010
- President, Biophysical Society Exocytosis &Endocytosis Subgroup 2004
- Appointed Member of Asian Institute of NanoBioScience and Technology 2003
- Humboldt Research Award (Alexander v.Humboldt Foundation Germany) 2003
- BS (PHYSICS, GENL (EXCL BIOPHYS)), UNIV OF HAMBURG (GER), 1977
- Ph D (PHYSICAL CHEMISTRY), TECH UNIV BERLIN (GER), 1983