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Manfred Lindau

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  • Manfred Lindau
  • Dept: Applied and Engineering Physics
  • Title: Professor
  • Address: 272 Clark Hall
  • Phone: 607 255-5264
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Biography

After receiving his doctorate from the Technical University of Berlin in 1983, Lindau was a postdoctoral associate at the Max-Planck-Institute for Biophysical Chemistry in Göttingen and at the Free University of Berlin, where he became an assistant professor in 1988. From 1992 through 1997 he was an associate member of the Max-Planck-Institute for Medical Research and taught biophysics at the University of Heidelberg. He joined the faculty at Cornell in 1997. He is active as a consultant in the areas of biophysics, physiology, and cell biology, and is a member of the Biophysical Society and the Society for Neuroscience.

Research Interests

The final aim of these experiments is the reduction of the exocytotic systems such that eventually isolated granules will be fused with plasma membrane patches and fusion among granules will be studied in vitro. The molecular reconstitution of fusion between vesicles and plasma membrane patches with properties similar to those of natural exocytotic events will provide a clear picture of the molecular machinery analogous to the previous demonstration that isolated protein complexes form functional ion channels when reconstituted into lipid membranes.

Selected Publications

  • Fang, Qinghua , Ying Zhao, Manfred Lindau. 2012. "Juxtamembrane tryptophans of synaptobrevin 2 control the process of membrane fusion." FEBS Letters 587 (1): 67-72.
  • Kima, Brian N., Adam D. Herbsta, Sung J. Kimc, Bradley A. Minch, Manfred Lindau. 2012. "Parallel recording of neurotransmitters release from chromaffin cells using a 10x10 CMOS IC potentiostat array with on-chip working electrodes." Biosensors and Bioelectronics 41: 736-744.
  • Lindau, Manfred, B. Hall, A. Chetwynd, O. Beckstein, M S.P Sansom. 2012. "Molecular dynamics simulations reveal synaptobrevin transmembrane domain movements in response to pico Newton forces." Biophysical Journal 103 (5): 959-969.
  • Lindau, Manfred. 2012. "High resolution electrophysiological techniques for the study of calcium-activated exocytosis." Biochemical, biophysical and genetic approaches to intracellular calcium signalling 1820 (8): 1234-1242.
  • Kisler, K., B N. Kim, X. Liu, K. Berberian, Q. Fang, C J. Mathai, S. Gangopadhya, K D. Gillis, Manfred Lindau. 2012. "Transparent Electrode Materials for Simultaneous Amperometric Detection of Exocytosis and Fluorescence Microscopy." Journal of Biomaterials Science 3 (2A): 243-253.

Selected Awards and Honors

  • Tau Beta Pi Engineering Honors Society Teaching Award (Tau Beta Pi) 2010
  • President, Biophysical Society Exocytosis &Endocytosis Subgroup 2004
  • President, Biophysical Society Exocytosis &Endocytosis Subgroup 2004
  • Appointed Member of Asian Institute of NanoBioScience and Technology 2003
  • Humboldt Research Award (Alexander v.Humboldt Foundation Germany) 2003

Websites

Education

  • BS (PHYSICS, GENL (EXCL BIOPHYS)), UNIV OF HAMBURG (GER), 1977
  • Ph D (PHYSICAL CHEMISTRY), TECH UNIV BERLIN (GER), 1983