Skip to main content

in this section

Chris Xu

  • Chris Xu
  • Dept: Applied and Engineering Physics
  • Title: Professor and Director of Undergraduate Studies
  • Address: 276 Clark Hall
  • Phone: 607 255-1460
  • return to list


Professor Xu joined Cornell faculty in the fall of 2002. Prior to that, he was a member of technical staff in Advanced Photonic Research at Bell Laboratories from 1999 to 2002. He joined Bell Laboratories as a postdoctoral member in 1997. Professor Xu received his Ph.D. from Cornell in the department of Applied and Engineering Physics in 1996, and earned his B.S. in physics from Fudan University in Shanghai. He is the recipient of the 2004 Tau Beta Pi Teaching Award, presented by the Cornell Society of Engineers. He was a recipient of the College of Engineering Teaching Award in 2005 and 2008. Besides technical publications, he has 28 patents granted or pending. He is a fellow of the National Academy of Inventors, and a fellow of the Optical Society of America.

Research Interests

Our research has two main thrusts: biomedical imaging and fiber optics. We are exploring new concepts and techniques for in vivo imaging deep into scattering biological specimens, such as mouse brain. We are developing new medical endoscopes for non-invasive real-time diagnostics of tissues without any exogenous contrast agent. We are developing novel optical fibers and fiber-based devices for biomedical imaging and optical communications.

Teaching Interests

Biomedical imaging and fiber optics

Selected Publications

  • Ouzounov, D. G., T. Wang, D. Feng, M. Wang, N. G. Horton, J. C. Cruz Hernández, Y. Cheng, J. Reimer, A. Tolias, N. Nishimura, Chris Xu. 2017. "In Vivo Three-Photon Imaging of Activity of GCaMP6-labeled Neurons Deep in Intact Mouse Brain." Nature methods.
  • Xu, Chris, Frank W Wise. 2013. "Recent advances in fiber lasers for nonlinear microscopy." Nature Photonics 7: 875-882.
  • Horton, N. G., K. Wang, D. Kobat, C. Clark, F. Wise, C. Schaffer, Chris Xu. 2013. "In vivo three-photon microscopy of subcortical structures of an intact mouse brain." Nature Photonics 7: 205-209.
  • Howard, S., A. Straub, N. Horton, D. Kobat, Chris Xu. 2013. "Frequency-multiplexed in vivo multiphoton phosphorescence lifetime microscopy." Nature Photonics 7: 33-37.
  • Rivera, D. R., C. M. Brown, D. G. Ouzounov, I. Pavlova, D. Kobat, W. W. Webb, Chris Xu. 2011. "Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue." Proceedings of the National Academy of Science 108 (43): 17598-17603.

Selected Awards and Honors

  • Fellow of the Optical Society of America (Optical Society of America) 2010
  • Best paper award (Microscopy & Microanalysis) 2015
  • Excellence in Teaching Award (Cornell University - College of Engineering) 2008
  • NSF CAREER Award (National Science Foundation) 2006
  • Excellence in Teaching Award (Cornell University - College of Engineering) 2005