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Chris Xu

  • Chris Xu
  • Dept: Applied and Engineering Physics
  • Title: Professor
  • Address: 276 Clark Hall
  • Phone: 607 255-1460
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Chris Xu is Professor of Applied and Engineering Physics, Cornell University, and the Mong Family Foundation Director of Cornell Neurotech - Engineering. His current research areas are fiber optics and biomedical imaging, with major thrusts in multiphoton microscopy for deep brain imaging, multiphoton microendoscopy for clinical applications, and fiber-based devices and systems for telecommunications and optical imaging. His research is supported by major grants from NIH, NSF, DARPA, and IARPA. Prior to Cornell, he was a Member of Technical Staff at Bell Laboratories. His main research focus at Bell Labs was on nonlinear imaging of semiconductor devices, fiber optics, and optical communications, including broadband access and ultralong haul transmission. He received his Ph.D. in Applied Physics, Cornell University, and his B.S. in Physics from Fudan University. He served as the Director of Graduate Studies in Applied Physics from 2007-2013. He currently serves as the Director of Undergraduate Studies of the School of Applied and Engineering Physics.

Dr. Xu has chaired or served on numerous conference organization committees and NSF/NIH review panels. He currently serves on the NIH NEI External Scientific Oversight Committee of the Audacious Goal Initiative and the OSA Biomedical Congress Strategic Planning Committee. He served as Associate Editor for Biomedical Optics Express, and is on the editorial boards of several journals. He has published 8 book chapters and more than 110 journal papers (> 8500 total citations, ISI Web of Science), and contributed more than 140 conference papers (including 8 postdeadline papers at CLEO and OFC). He has delivered over 200 plenary/keynote/invited conference presentations, research seminars, and outreach talks. He holds 24 patents on optical communications and imaging. He has won the NSF CAREER award, Bell Labs team research award, and the Tau Beta Pi and two other teaching awards from Cornell Engineering College. He is a fellow of the National Academy of Inventors, and a fellow of the Optical Society of America.

Research Interests

Our research has two main thrusts: biomedical imaging and fiber optics. We are exploring new concepts and techniques for in vivo imaging deep into scattering biological specimens, such as mouse brain. We are developing new medical endoscopes for non-invasive real-time diagnostics of tissues without any exogenous contrast agent. We are developing novel optical fibers and fiber-based devices for biomedical imaging and optical communications.

Teaching Interests

Biomedical imaging and fiber optics

Selected Publications

  • Ouzounov, D. G., T. Wang, M. Wang, D. Feng, N. G. Horton, J. C. Cruz-Hernández, Y. Cheng, J. Reimer, A. Tolias, N. Nishimura, Chris Xu. 2017. "In vivo three-photon imaging of activity of GCaMP6-labeled neurons deep in intact mouse brain." Nature methods.
  • Xu, Chris, Frank W Wise. 2013. "Recent advances in fiber lasers for nonlinear microscopy." Nature Photonics 7: 875-882.
  • Horton, N. G., K. Wang, D. Kobat, C. Clark, F. Wise, C. Schaffer, Chris Xu. 2013. "In vivo three-photon microscopy of subcortical structures of an intact mouse brain." Nature Photonics 7: 205-209.
  • Howard, S., A. Straub, N. Horton, D. Kobat, Chris Xu. 2013. "Frequency-multiplexed in vivo multiphoton phosphorescence lifetime microscopy." Nature Photonics 7: 33-37.
  • Rivera, D. R., C. M. Brown, D. G. Ouzounov, I. Pavlova, D. Kobat, W. W. Webb, Chris Xu. 2011. "Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue." Proceedings of the National Academy of Science 108 (43): 17598-17603.

Selected Awards and Honors

  • Fellow of the National Academy of Inventors 2014
  • Fellow of the Optical Society of America (Optical Society of America) 2010
  • Excellence in Teaching Award (Cornell University - College of Engineering) 2008
  • NSF CAREER Award (National Science Foundation) 2006
  • Excellence in Teaching Award (Cornell University - College of Engineering) 2005