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Warren R. Zipfel

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  • Warren R. Zipfel
  • Dept: Biomedical Engineering
  • Title: Associate Professor
  • Address: B41 Weill Hall
  • Phone: 607 255-0663
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Biography

My primary research focus is on the development and application of optical microscopy for biomedical research and for clinical imaging applications using nonlinear microscopy, endoscopy and laparoscopy. The biological research focus in my lab is in the area of optical detection of cancer, and collaborative studies in cancer biology using transgenic mouse models of ovarian, mammary and prostate cancer. I serve as Director of the Developmental Resource for Biophysical Imaging and Optoelectronics (DRBIO), the NIH-funded center that originally developed multiphoton imaging in 1990. My lab is also involved in numerous optical instrumentation development projects and the creation of new bioanalytical methods for studies in cell signaling and regulation.

Research Interests

My engineering research focus is on the development and application of optical microscopy for biomedical research and for clinical imaging applications, with a primary effort on nonlinear microscopy. I serve as Director of the Developmental Resource for Biophysical Imaging and Optoelectronics (DRBIO), the NIH-funded center that originally developed multiphoton imaging in 1990. My lab is involved in numerous optical instrumentation development projects and the creation of new bioanalytical methods for studies in cell signaling and regulation. The biological research focus in my lab has been in the areas of optical detection of cancer, and collaborative studies in cancer biology, transcription and nuclear regulation and in neurobiology.

Selected Publications

  • Lukk, T., R E. Gillilan, D M. Szebenyi, W R Zipfel. 2016. "A visible-light-excited fluorescence method for imaging protein crystals without added dyes.." Journal of Applied Crystallography 49 (1): 234-240.
  • Kushner, M., A. Van Slyke, F. Rinaldi, A. Singh, J. Lis, A. Bogdanove, W Zipfel. 2016. "Examining Tale Protein Binding Kinetics and Site Competition using Single Molecule Imaging." Biophysical Journal 110 (3): 238a-238a.
  • Singh, A., M. Sirenko, A. Song, P J. Kammermeier, W R Zipfel. 2016. "Stoichiometric Analysis of Protein Complexes by Cell Fusion and Single Molecule Imaging." Biophysical Journal 110 (3): 637a-638a.
  • Sirenko, M., A. Singh, A. Song, P. Kammermeier, W Zipfel. 2016. "Determining the Stoichiometry of EGFR and ADRβ2 using Cell Fusion and Single Molecule Imaging." Biophysical Journal 110 (3): 640a-640a.
  • Van Slyke, A L., A. Singh, F. Cupri Rinaldi, A J. Bogdanove, J T. Lis, W R Zipfel. 2016. "Investigating the Kinetics and Specificity of Transcription Activator-Like Effector Binding using High Throughput Single Molecule Imaging." Biophysical Journal 110 (3): 640a-640a.

Selected Awards and Honors

  • Avtar Singh - NSF Fellowship 2010

Websites

Education

  • BS (Biochemistry), Cornell University, 1987
  • Ph D (Biophysics), Cornell University, 1993